Sequence-controlled supramolecular terpolymerization directed by specific molecular recognitions

Polyvalent carbocyanine molecular beacons for molecular recognitions.

Polyvalent carboxylate-terminating near-infrared (NIR) carbocyanine molecular beacons were prepared by homologation of reactive carboxyl groups of the beacon with imino diacetic acid. Their conjugation with unprotected d-(+)-glucosamine gave dendritic arrays of the carbohydrate on an inner NIR chromophore core. In vivo evaluation of the dendritic glucosamine constructs shows enhanced uptake in ...

Molecular basis for the specific and multivariate recognitions of RNA substrates by human hnRNPA2/B1

Modulating Molecular Properties by Supramolecular Interactions

Supramolecular interaction is rapidly emerging as the method of choice for tuning molecular properties to meet desired applications like drug delivery vehicles, sensors, designing molecular architectures, catalysis chambers, biomimetic systems and so on. We have successfully demonstrated the modulation of electron and proton transfer reactions, acidbase characteristics and photophysical propert...

Nanostructured organic semiconductors via directed supramolecular assembly.

Organic small molecule semiconductors have many advantages over their polymer analogues. However, to fabricate organic semiconductor-based devices using solution processing, it is requisite to eliminate dewetting to ensure film uniformity and desirable to assemble nanoscopic features with tailored macroscopic alignment without compromising their electronic properties. To this end, we present a ...

Sequence-directed DNA translocation by purified FtsK.

DNA translocases are molecular motors that move rapidly along DNA using adenosine triphosphate as the source of energy. We directly observed the movement of purified FtsK, an Escherichia coli translocase, on single DNA molecules. The protein moves at 5 kilobases per second and against forces up to 60 piconewtons, and locally reverses direction without dissociation. On three natural substrates, ...